Stimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G.
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منابع مشابه
Stimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G.
Human leukocyte cathespin G strongly stimulates the rate of solubilization of human lung elastin by human leukocyte elastase. For instance, the elastolytic activity of an equimolar mixture of elastase and cathepsin G is more than 5 times higher than that of elastase alone. Optimal stimulation occurs only if cathepsin G and elastase act simultaneously on elastin. Potentiation of leukocyte elasta...
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Three alpha-aminoboronic acid-containing analogs of good peptide substrates for serine proteases were synthesized, MeO-Suc-Ala-Ala-Pro-boro-Phe-OH, MeO-Suc-Ala-Ala-Pro-boro-Ala-OH, and MeO-Suc-Ala-Ala-Pro-boro-Val-OH. They were effective inhibitors of chymotrypsin, cathepsin G, and both leukocyte and pancreatic elastase at nanomolar concentrations (0.10-20 nM). Except for cathepsin G, inhibitio...
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Azurocidin was purified in the presence of phenylmethylsulfonyl fluoride. Electrophoresis revealed at least seven species which exhibited N-terminal sequences consistent with azurocidin. Azurocidin exhibited no bactericidal activity against Capnocytophaga sputigena or other oral bacteria but synergized the bactericidal activity of enzymatically active elastase. Azurocidin also interacted synerg...
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Polymorphonuclear leukocytes (PMN) when activated release products that can potentially injure endothelial cells or alter endothelial function. Exposure of cultured human umbilical vein endothelial cells to cathepsin G and elastase isolated from human PMN at concentrations reached in vivo (100 ng/mL to 10 micrograms/mL) selectively inhibited thrombin-induced prostacyclin production and the thro...
متن کاملEnhancement of Cathepsin G-Induced Platelet Activation by Leukocyte Elastase: Consequence for the Neutrophil-Mediated Platelet Activation
W e have focused our interest on the platelet-activating properties of two polymorphonuclear neutrophil (PMN)-derived proteinases, namely elastase (HLE) and cathepsin G (Cat.G). First of all, we observed that whereas HLE was unable to trigger platelet activation by itself, it enhanced platelet activation induced by Cat.G when both proteinases were added simultaneously. It has been recently desc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1981
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)68612-6